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Women with hormonal drivers (especially around perimenopause and menopause) should also get a hormone evaluation, since addressing underlying hormonal shifts is often part of an effective protocol

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NNMT normally burns through NAD+ precursors as a kind of metabolic "bleed." Block the bleed, and MOTS-C's expanded mitochondrial activity has more substrate to work with

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Meanwhile, postmortem studies have shown dopaminergic dysfunction in circuits involving the basal ganglia, anterior cingulate, and frontal cortices (Lai et al., 2011

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